Warm, cheesy, and packed with protein, Tuna and Broccoli Bake is the comfort food classic you didn’t know you needed this week. It’s an easy win for busy weeknights or meal prep.

Broccoli and tuna create a nutritious, hearty base while creamy Cheddar and Bisquick deliver that irresistible golden crust. The result? A bubbly bake that’s satisfying without being heavy.

What You’ll Need for This Tuna and Broccoli Bake

Fresh broccoli florets – Adds texture, fiber, and a vibrant green contrast to the rich, cheesy base.
Tuna in water – The star protein, bringing a mild seafood flavor that balances beautifully with dairy and vegetables.
Shredded Cheddar cheese – Melts into gooey goodness, infusing every bite with creamy, sharp depth.
Original Bisquick™ mix – Forms the structure of the bake, giving it a light, almost quiche-like lift.
Sour cream – Delivers tang and creaminess that complements the savory layers.
Milk – Helps to blend the batter and adds richness without heaviness.
Eggs – The binder that pulls everything together and sets the bake perfectly.

Let’s Bake: Tuna and Broccoli Edition

Start by preheating your oven and prepping your baking dish. Layer the broccoli, tuna, and most of the cheese at the base—this builds flavor and texture from the bottom up.

In a separate bowl, whisk together the Bisquick mix, sour cream, milk, and eggs until smooth. Pour this mixture gently over the layered ingredients to create a custard-like base.

Bake until golden and set in the center. A quick cheese sprinkle at the end adds that final touch of melt and shine. Let it rest briefly before slicing into creamy, cheesy perfection.

Tips, Tweaks, and Simple Successes

For extra flavor, try adding sautéed onions or a pinch of garlic powder to the batter mix. Prefer a little crunch? A handful of crushed crackers or breadcrumbs sprinkled on top before baking delivers a crisp golden crown.

This recipe is also incredibly flexible—swap the tuna for shredded rotisserie chicken or mix in chopped spinach with the broccoli. Want a kick? Stir a bit of Dijon mustard or hot sauce into the egg mixture to elevate the flavor complexity.

Make it gluten-free by using a gluten-free baking mix in place of Bisquick. Just keep the proportions similar, and check consistency before baking.

Leftover Love: Storing and Reheating Tips

Once cooled, cover any leftovers tightly or transfer them to airtight containers. The bake keeps well in the fridge for up to three days and reheats beautifully in the microwave or oven.

To freeze, cut into individual portions and wrap well. Reheat directly from frozen in the oven at 350°F until warmed through, about 25–30 minutes. Perfect for make-ahead lunches or dinners when time is tight.